Description
Cofafer is an injectable solution for the treatment and prevention of iron deficiency anaemia
Active Substance(s):
Iron ……………… 100mg (as dextran)
Excipient(s):
Phenol ……………………… 5mg
Clinical information
Target species
Pigs (piglets), cattle (calves), sheep (lambs) and goats (kids).
Indications for use, specifying the target species
In piglets, calves, lambs and kids:
– Treatment and prevention of iron deficiency anaemia.
Contraindications
Do not use in animals with known hypersensitivity to iron (as dextran).
Special precautions for use
ii) Special precautions to be taken by the person administering the veterinary medicinal product to animals
In case of accidental self-injection, seek medical advice immediately and show the label to the physician.
Side effects (frequency and seriousness)
Discoloration at the injection site.
Occasionally, anaphylactic shock has been observed after parenteral administration of iron (as dextran).
Very rare cases of piglet deaths have occurred after parenteral administration of iron preparations. These deaths were associated with genetic factors or vitamin E and/or selenium deficiencies.
Use during pregnancy, lactation or lay
Not applicable.
Drug interactions and other forms of interaction
None known.
Dosage And Route Of Administration
Piglets:
– 100 to 200 mg of iron per animal, by deep intramuscular route preferably in the spine within 3 days following birth, ie 1 mL to 2 mL in a single injection.
Calves:
– 300 to 400 mg of iron per animal, intramuscularly or subcutaneously via baleen within 3 days of birth, ie 3 mL to 4 mL in a single injection.
Lambs and kids:
– 100 to 200 mg of iron per animal, intramuscularly or subcutaneously within 3 days following birth, ie 1 mL to 2 mL in a single injection.
The injection can be renewed if necessary after 8 days or 1 month.
Pharmacological Properties
Pharmacotherapeutic group: Injectable antianaemic preparations based on iron dextran.
ATC vet code: QB03AC90.
Pharmacodynamic Properties
Iron dextran is an anti-anaemic acting by significantly increasing the hemoglobin level. After administration, the iron is stored in the tissues, then gradually released from the complex with the dextran. It is incorporated into hemoglobin in the form of proteins such as ferritin and hemosiderin. Iron is administered in the form of an iron dextran complex to avoid toxic effects of free iron.
Pharmacokinetic Characteristics
After administration, approximately 60% of the iron is absorbed after 3 days and 90% after 1 to 3 weeks.
Pharmaceutical Information
List of excipients
Phenol
Copper
gluconate Zinc
gluconate Cobalt gluconate
Water for injections
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