Description

Xylazine 50ml

Xylazine is a sedative and analgesic as well as a muscle relaxant. Xylazine HCl Injection is used in horses to produce a state of sedation accompanied by a shorter period of analgesia. A sleeplike state is usually maintained for 1-2 hours, while analgesia lasts from 15-30 minutes.

Xylazine HCl Injection may be used to calm horses and facilitate handling or during clinical examinations, orthopedic procedures, dental procedures and surgical procedures. Xylazine HCl Injection is also used as a pre-anesthetic to general anesthesia or in conjunction with local anesthetics. Contains 100 mg xylazine per ml. Biovitaion 100ml

Dosage And Administration

Horse Dosage:

   Intravenously−0.5 mL/100 lbs body weight (0.5 mg/lb)
Intramuscularly−1.0 mL/100 lbs body weight (1.0 mg/lb)

Following injection of Xylazine (xylazine injection), the animal should be allowed to rest quietly until the full effect has been reached. These dosages produce sedation which is usually maintained for 1 to 2 hours, and analgesia which lasts for 15 to 30 minutes.

Preanesthetic to Local Anesthesia: Xylazine at the recommended dosages can be used in conjunction with local anesthetics, such as procaine or lidocaine.

Preanesthetic to General Anesthesia: Xylazine at the recommended dosage rates produces an additive effect to central nervous system depressants such as pentobarbital sodium, thiopental sodium and thiamylal sodium. Therefore, the dosage of such compounds should be reduced and administered to the desired effect. In general, only 1/3 to 1/2 of the calculated dosage of the barbiturates will be needed to produce a surgical plane of anesthesia.

Post-anesthetic or emergence excitement has not been observed in animals preanesthetized with Xylazine.

Xylazine has been used successfully as a preanesthetic agent for pentobarbital sodium, thiopental sodium, thiamylal sodium, nitrous    oxide, ether, halothane, glyceryl guaiacolate, and methoxyflurane anesthesia.

Cervidae Dosage:

Administer intramuscularly, by either hand syringe or syringe dart, in the heavy muscles of the croup or shoulder. Cervidae Dosage Range:

Fallow Deer (Dama dama)−2.0 to 4.0 mL/100 lbs body weight (2.0 to 4.0 mg/lb).
Mule Deer (Odocoileus hemionus)−1.0 to 2.0 mL/100 lbs body weight (1.0 to 2.0 mg/lb).
Sika Deer (Cervus nippon)−1.0 to 2.0 mL/100 lbs body weight (1.0 to 2.0 mg/lb).
White-Tailed Deer (Odocoileus virginianus)−1.0 to 2.0 mL/100 lbs body weight (1.0 to 2.0 mg/lb).
Elk (Cervus canadensis)−0.25 to 0.5 mL/100 lbs body weight (0.25 to 0.5 mg/lb).

Following injection of Xylazine the animal should be allowed to rest quietly until the full effect has been reached.

These dosages produce sedation which is usually maintained for 1 to 2 hours and analgesia which lasts for 15 to 30 minutes.

Storage Directions

Store at 20°C – 25°C (68°F to 77°F). Do not freeze.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

 

Xylazine Pharmacology

Xylazine, a non-narcotic compound, is a sedative and analgesic as well as muscle relaxant. Its sedative and analgesic activity is related to central nervous system depression. Its muscle- relaxant effect is based on inhibition of the intraneural transmission of impulses in the central nervous system. The principal pharmacological activities develop within 10 to 15 minutes after intramuscular injection, and within 3 to 5 minutes following intravenous administration in horses.

A sleeplike state, the depth of which is dose-dependent, is usually maintained for 1 to 2 hours, while analgesia lasts from 15 to 30 minutes. The centrally-acting muscle relaxant effect causes relaxation of the skeletal musculature, complementing sedation and analgesia.

In horses and Cervidae under the influence of Xylazine (xylazine injection), the respiratory rate is reduced as in natural sleep. Following treatment with Xylazine (xylazine injection), the heart rate is decreased and a transient change in the conductivity of the cardiac muscle may occur, as evidenced by a partial atrioventricular block.

This resembles the atrioventricular block often observed in normal horses.1,2,3,4 Although a partial A-V block may occasionally occur following intramuscular injection of Xylazine (xylazine injection), the incidence is less than when it is administered intravenously. Intravenous administration of Xylazine (xylazine injection) causes a transient rise in blood pressure, followed by a slight decrease. Strange Viper 10ml

Xylazine has no effect on blood clotting time or other hematologic parameters.

 

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